Integrins is an important adhesion molecule in cells and extracellular matrix and cell-cell adhesion.Previous studies have confirmed that integrins and tumor metastasis are closely related,but literature analysis shows that this area of research in tumor has been a hot spot.This article focuses on an overview of the past five years,international research about the mechanisms of integrin-mediated tumor metastasis.The data available demonstrated that integrin modulates a large number of non-ligand signaling p...