【摘要】 目的通过观察慢性心力衰竭(CHF)患者N末端脑钠肽前体(NT-proBNP)水平及其与心脏左室射血分数(LVEF)的相关性,探讨NT-proBNP在CHF诊断中的应用价值。方法选取38例CHF患者为CHF组,30例无器质性心脏病者为对照组,分别检测血清NT-proBNP水平,心脏彩色多普勒超声测定LVEF,对比2组血清NT-proBNP水平,并分析其与LVEF的相关性。结果 CHF组患者血清NT-proBNP水平显著高于对照组(P<0.01),并随NYHA心功能级别增高而升高(P<0.01),随LVEF下降而升高(P<0.01)。结论 NT-proBNP检测为心力衰竭诊断提供一量化指标,具有重要的临床应用价值。更多还原

【Abstract】 Objective To investigate the value of N terminal pro-brain natriuretic peptide(NT-pro BNP) in the diagnosis of chronic heart failure through observing the NT-proBNP level in patients with chronic heart failure(CHF) and the correlation between them and left ventricular ejection fraction(LVEF).Methods Thirty-eight patients with CHF(CHF)and 30 healthy people without structural heart disease(control) were studied.The level of serum NT-proBNP was detected and LVEF was determined by cardiac color Doppler ultrasound.Serum NT-proBNP levels of two groups were compared and the relationship between serum NT-proBNP levels and LVEF were assessed.Results Serum NT-proBNP levels of the CHF group were significantly higher than those of control group(P<0.01),and increased with the rise of NYHA functional class(P<0.01),and increased with the decline of LVEF(r=-0.6190,P<0.01).Conclusion Detecting the NT-proBNP provides a quantitative index for the diagnosis of heart failure,thus it is of important clinical value.更多还原