【摘要】 目的观察帕米膦酸二钠(博宁)联合同期化疗治疗乳腺癌骨转移的疗效。方法将79例乳腺癌骨转移患者随机分为试验组(40例)和对照组(39例)。试验组静脉滴注帕米膦酸二钠90 mg联合同期化疗,对照组单纯行同期化疗。结果试验组与对照组止痛有效率、生活质量提高率和骨质修复有效率分别为90.0%,87.5%,75.50%和74.4%,64.1%,43.59%,两组比较差异具有统计学意义(P<0.05)。结论帕米膦酸二钠联合同期化疗对乳腺癌骨转移患者在止痛、生活质量改善和骨质修复方面疗效明显。更多还原

【Abstract】 Objective To evaluate the curative effect of Pamidronate Disodium combined with concurrent chemotherapy for the treatment of breast cancer patients with bone metastases.Methods Seventy-nine patients with metastatic tumor of bone were randomly divided in to Binin group(40 cases) and control group(39 cases).The Bonin group received 90 mg Pamidronate by intravenon infusion combined with concurrent chemotherapy;the control group was only treated with concurrent chemotherapy.Results The overall response rates of the Bonin group and control group were 96.8% and 74.2%,respectively(P<0.05).The overall response rate of movement capacity improvement was 90.0% in the Binin group and 74.4% in the control group(P<0.05).The overall response rate of the life quality improvement was 87.5% in the Bonin group and 64.1% in the control group(P<0.05).The overall response rate of bone mineral density recovery was 75.50% in the Bonin group and 43.59% in the control group(P<0.05).Conclusion Bonin combined with concurrent chemotherapy can remarkably relieve bone pain,improve life quality,bone mineral density in breast cancer patients with bone metastases.更多还原