【摘要】 目的:探讨紫杉醇配合精心的护理与同期放化疗治疗复发鼻咽癌的效果。方法:42例复发性鼻咽癌患者随机分为两组,21例为适形放疗+紫杉醇(紫杉醇组),另21例为顺铂+5-氟尿嘧啶(PF)方案化疗+常规放疗(PF组)。结果:两组在治疗结束时鼻咽部病灶有效率(PR+CR)差异均无统计学意义(P>0.05);两组胃肠道反应、口腔黏膜反应、白细胞下降和皮肤反应,主要发生在PF组,为Ⅱ～Ⅳ度,紫杉醇为0-I。而脱发主要见于紫杉醇组,多为Ⅱ～Ⅲ度,而PF组0～I度为主;耐受度指数紫杉醇组为(8±2.8)分,PF组为(3±1.3)分,差异有统计学意义(P<0.05)。结论:紫杉醇组与PF方案鼻咽癌局部控制率相近,但不良反应较轻。更多还原

【Abstract】 Objective:To study the effects of paclitaxel chemotherapy in combination with conformal radiotherapy coordinated by elaborate nursing in the treatment of recurrent nasopharyngeal carcinoma.Methods:42 cases of recurrent nasopharyngeal carcinoma were randomly divided into two groups.In paclitaxel group,21 cases received concurrent paclitaxel and conformal radiotherapy,and in group PF,21 cases received PF chemotherapy and routine radiotherapy.Results:After finishing the whole therapy,the response rates(PR+CR) to nasopharyngeal lesions showed no statistical difference between the two groups.The main toxicities including lesions of mucous,skin reactions,gastrointestinal reactions and leucopenia occurred more frequently in the group PF(mainly degree Ⅱ-Ⅳ),and which in paclitaxel group were mainly degree 0-I.The tolerance index was 8±2.8 in the paclitaxel group and 3±1.3 in the group PF,showing statistical difference(P<0.05).Conclusion:The local control rate of the paclitaxel group for treating recurrent nasopharyngeal carcinoma is similar to that of the group PF,but with milder adverse reactions.更多还原