【摘要】 目的:探讨脊髓损伤后的自我保护修复机制。方法:采用改良的Allen’s法建立SD大鼠T11节段脊髓损伤模型,观察术后不同时间段脊髓内碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)蛋白表达分布及变化情况。结果:脊髓损伤各时间段bFGF阳性神经元数较正常组显著增加。7 d达高峰,21 d恢复正常。结论:脊髓损伤后bFGF表达,提示其参与了脊髓损伤后神经元的保护作用。更多还原

【Abstract】 Objective:To study the mechanisms of self-repair following spinal cord injury(SCI).Methods:We adopted the T11 SCI model in SD rat by Allen’s improved methods.Expressions and changes of basic fibroblast growth factor(bFGF) were observed in postoperative different time periods by immunohistochemical method.Results:bFGF positive neurons in SCI group during different time periods were significantly increased than those in the normal group,which reached the climax on 7d and restored to normal level on 21d.Conclusion:Changing in the expression of bFGF after SCI suggests that bFGF participates the protection role of neurons after SCI.更多还原