【摘要】 目的探讨特异性免疫治疗对慢性鼻窦炎(CRS)伴变应性鼻炎患者功能性内镜鼻窦手术(FESS)效果的影响。方法将确诊为CRS伴常年性变应性鼻炎的57例患者按照尘螨过敏与否分成两组,尘螨过敏者为治疗Ⅰ组,FESS术后采用皮下免疫治疗;非尘螨过敏者为治疗Ⅱ组,单纯行FESS。分别对两组患者术前、术后6个月、术后1年的症状及体征进行评分并对比,采用鼻腔鼻窦结局测试-20(SNOT-20)量表及Lund-Kennedy鼻内镜评分法。结果两组患者术后6个月和1年的SNOT-20及Lund-Kennedy评分较术前均有明显改善(P<0.01),治疗Ⅰ组患者的疗效优于治疗Ⅱ组且组间差异有统计学意义(P<0.05)。结论特异性免疫治疗可改善CRS伴变应性鼻炎患者的手术效果。更多还原

【Abstract】 Objective To investigate the effect of specific immunotherapy on outcomes after functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis(CRS) with allergic rhinitis.Method Fifty-seven CRS patients accompanied with perennial allergic rhinitis were divided into two groups according to the results of allergen skin prick test.Those who were allergic to dust mites,the treatment groupⅠ,were treated with subcutaneous immunotherapy after FESS,others were treatment groupⅡand treated with FESS merely.Before and 6,12 months after FESS,the nasal symptoms and signs of all patients were evaluated by sino-nasal outcome test-20(SNOT-20) and Lund-Kennedy endoscopic scores,and compared with each other.Results Compared to the scores before FESS,the SNOT-20 and Lund-Kennedy scores of two groups are significantly improved in 6 months and one year after FESS(P<0.01).Significantly better curative effects were obtained in the treatment groupⅠwhen compared with the treatment groupⅡ(P<0.05).Conclusion Specific immunotherapy may improve the surgical outcomes in CRS patients with allergic rhinitis.更多还原