【摘要】 研究藏药狭叶红景天的化学成分,应用硅胶、ODS和Sephadex LH-20凝胶柱色谱以及反相HPLC等多种技术进行分离和纯化,应用波谱技术确定化合物的结构。从藏药狭叶红景天乙醇提取物中分离鉴定了11个化合物,其中4-羟基-苯乙基-(4′-甲氧基-苯乙基)醚(1)和β-D-葡萄糖苷-2-羟基-2-甲基-丁酸酯(2)为新化合物;对乙氧基苯乙醇乙酯(3),对羟基苯甲酸乙酯(5),对羟基苯甲醛(7),R(-)-mellein(8),对甲氧基苯乙醇(10)5个化合物为首次从红景天属植物中得到,对羟基苯乙酮(4),对羟基苯甲酸(6),豆甾醇(9),3,4,5-三羟基苯甲酸甲酯(11)4个化合物为首次从狭叶红景天中得到。更多还原

【Abstract】 Chemical constituents of the whole herb of Rhodiola kirilowii(Regl) Maxim.were investigated.The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel,ODS,Sephadex LH-20 and reversed-phase HPLC.Their structures were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy.Eleven compounds were obtained and identified as 4-hydroxyphenylethyl-(4’- methoxyphenylethyl)ether(1),1-(2-hydroxy-2-methylbutanoate)-β-D-glucopyranose(2),4-ethoxy-phenylethanol acetate(3),p-hydroxyacetophenone (4),p-hydroxy-benzoic acid ethylester(5),4-hydroxybenzoic acid(6),4-hydroxybenzaldehyde(7),R(-)-mellein (8),stigmasterol(9),4-methoxy-phenylethanol(10),and methylgallate(11).Among them,1 and 2 are new compounds; compounds 3,5,7,8,and 10 were isolated from Rhodiola genus for the first time;and compounds 4,6,9,and 11 were isolated from Rhodiola kirilowii(Regl) Maxim.for the first time.更多还原