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1,4-二氢噻吩并[3’,2’:5,6]噻喃并[4,3-c]吡唑-3-羧酸衍生物的合成及抗癌活性研究(英文)
Synthesis and anti-tumor activity of 1,4-dihydrothieno[3’,2’:5,6] thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives
【摘要】 本文以2-巯基噻吩为原料,经6步反应合成了5个1,4-二氢噻吩并[3’,2’:5,6]噻喃并[4,3-c]吡唑-3-羧酸衍生物,并采用人乳腺癌细胞MCF-7对目标化合物的抗肿瘤活性进行初步评价。所合成化合物在100μM浓度下均有一定的抑制MCF-7活性。
【Abstract】 Five 1,4-dihydrothieno[3’,2’:5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives were synthesized from 2- mercaptothiophene via a six-step procedure. The prepared compounds were initially evaluated for their antiproliferative activity using the estrogen receptors expressing MCF-7 human mammary tumor cell line in vitro. All of the prepared compounds showed moderate anti-tumor activity.
【关键词】 合成；
1,4-二氢噻吩并[3’,2’,6]噻喃并[4,3-c]吡唑-3-羧酸衍生物；
抗癌活性；
【Key words】 Synthesis； 1,4-Dihydrothieno[3’,2’,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives； Anti-tumor activity；
【Key words】 Synthesis； 1,4-Dihydrothieno[3’,2’,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives； Anti-tumor activity；
【基金】 National Natural Science Foundation of China (Grant No. 20474053)
- 【文献出处】 Journal of Chinese Pharmaceutical Sciences ,中国药学(英文版) , 编辑部邮箱 ,2011年01期
- 【分类号】R96;TQ460.1
- 【被引频次】1
- 【下载频次】158