【摘要】 目的:探讨40岁以下青年急性心肌梗死(AMI)患者的冠状动脉病变特征及临床特点。方法:2007年1月至2010年12月我院经急诊或择期冠状动脉介入诊疗明确诊断的AMI患者共415例,其中年龄≤50岁的中青年患者126例,按年龄分为两组:青年组(29例),年龄≤40岁;中年组(97例),40岁<年龄≤50岁。对两组冠状动脉病变特征及临床特点进行回顾性分析,所有病例随访3个月。结果:青年组大量吸烟者(20支/d,10年以上)显著多于中年组(55.2%比30.9%);合并糖尿病和高血压者显著少于中年组(3.4%比23.7%,27.6%比41.2%),合并血脂异常者显著多于中年组(58.6%比36.1%)。梗死相关血管分布特点两组间无显著差异(P>0.05);但冠状动脉单支病变者青年组显著多于中年组(72.4%比43.3%)。住院期间青年组无一例死亡,中年组死亡两例。结论:大量吸烟和血脂异常为40岁以下青年急性心肌梗死患者的主要发病因素,合并糖尿病及高血压者相对少见,单支血管病变多见,住院期死亡率低,短期预后好。更多还原

【Abstract】 Objective:To investigate the clinical characteristics and features of coronary artery disease of ≤40 years old young patients with acute myocardial infarction(AMI).Methods:A total of 415 patients of our hospital were definitely diagnosed as AMI through primary or delayed percutaneous coronary intervention from January 2007 to December 2010,in which 126 patients with age ≤50 years old,and they were divided into two groups according age:young group(n=29,age ≤40 years old);middle-aged group(n=97,40 years<age≤50 years old).Clinical characteristics and features of coronary artery disease of the two groups were retrospectively analyzed and followed up for three months.Results:There were more heavy smokers(20 cigarettes/d,>10 years) in young group than that of middle-aged group(55.2% vs.30.9%);patients complicated diabetes and hypertension in young group were significantly fewer than those of middle-aged group(diabetes:3.4% vs.23.7%,hypertension:27.6% vs.41.2%),cases complicated dyslipidemia in young group was significantly more than that of middle-aged group(58.6% vs.36.1%).Distributive characteristics of infarct-related artery showed no significant difference between the two groups(P>0.05);but patients with single-vessel coronary disease in young group were significantly more than that of middle-aged group(72.4% vs.43.3%).No one died in young group and two cases died in middle-aged group during admission.Conclusion:Heavy smoking and dyslipidemia are the main risk causes for AMI patients aged 40 years old or younger.In these patients,there are relatively few cases complicated diabetes and hypertension,more single-vessel coronary disease and short-term prognosis is good.更多还原