【摘要】 目的观察较长疗程的灯盏花素对急性脑缺血恢复期的保护作用。方法采用改良的Zealonga法建立大鼠大脑中动脉局灶缺血/再灌注梗死(MCAO)模型。将60只大鼠随机分为模型组(A组,生理盐水2.7ml/kg,×7天)、短期给药组(B组,灯盏花素2.7ml/kg,×7天)、较长期给药组(C组,灯盏花素2.7ml/kg,×28天)及对照组(D组)。分别于术后1小时,1、2、4周末进行前肢放置试验神经功能评分,并光镜下HE染色观察神经组织形态。结果神经行为学评分提示,两给药组与模型组比较有显著性差异(P<0.05),且较长期给药组效果优于短期给药组(P<0.05)。光镜提示较长期给药组镜下组织学改变较小。结论较长疗程使用灯盏花素对脑缺血恢复期有更好的保护作用和神经行为学改善。更多还原

【Abstract】 Objective To observe the protection of breviscapine on restoration stage of focal cerebral ischemia in rats.Methods 60 SD rats were randomized into model group,short-term treatment group,long-term treatment group and sham group.The forelimd-placement test were detected.After lh,1w,2w and 4w of focal ischemia,the pathological changes were observed by light microscope.Results The neuroethology scores of treatment group were different from that of model group.The pathological changes were more minimal in the long-term treatment group than that in other groups.Conclusion Breviscapine has neuroprotective effects in restoration stage of focal cerebral ischemia.更多还原