【摘要】 目的观察新辅助化疗(NACT)的临床疗效以及NACT前后宫颈癌组织中微血管密度(MVD)的变化。方法采用免疫组化SP法检测29例宫颈鳞癌组织NACT前后CD34的表达。结果 29例宫颈癌患者接受NACT后,临床完全缓解(CR)4例(13.8%),部分缓解(PR)21例(72.4%),总有效率(CR+PR)86.2%;在所有接受NACT的29例宫颈癌组织中,MVD水平在NACT后(13.57±5.60)较NACT前(20.65±7.17)亦有明显下降(P<0.05);临床有效组MVD计数在NACT后(14.27±5.49)较NACT前(22.17±6.55)显著下降(P<0.05),临床无效组MVD计数在NACT后(19.02±5.70)较NACT前(24.98±9.42)亦有明显下降(P<0.05)。结论 NACT对宫颈癌有效;NACT后MVD表达下降。NACT发挥效应的机制之一可能为抑制肿瘤血管生成。更多还原

【Abstract】 Objective To investigate the clinical effect of neoadjuvant chemotherapy(NACT) and its influence on the expressions of MVD.Methods The expressions of CD34 were determined by immunohistochemistry in 29 cases of cervical cancer before and after NACT.Results Among the 29 cases treated with NACT,4(13.8%) were complete remission(CR),21(72.4%) partial remission(PR).The total effective rate of NACT(CR+PR) was 86.2%.The expressions of MVD decreased dramatically after NACT.3.In cases who reacted positively to NACT,the level of MVD decreased significantly after the treatment(P<0.05).And in cases who reacted poorly to NACT the level of MVD also decreased in those cases(P<0.05).Conclusion NACT is an effective treatment for cervical cancer.The level of MVD decreased after NACT.It was supposed that one of the mechanisms of NACT may be the suppression of angiogenesis.更多还原