【摘要】 目的探讨抗环瓜氨酸酞(ccp)抗体与AKA、RF对类风湿关节炎(RA)的诊断意义,并了解其与抗角蛋白抗体(AKA)及类风湿因子(RF)之间的相关性。方法采用ELISA法,共检测296例患者的血清抗CCP抗体和AKA、RF抗体,其中RA 137例,非RA 159例。结果抗CCP抗体的阳性率在RA患者中为98.2%,在非RA中为3.9%。并且3种抗体对RF诊断的敏感性和特异性分别为CCP 98.2%、95.4%;AKA 49.1%、94.3%;RF 86%、83%。抗CCP抗体与AKA、RF之间显著相关(P<0.01)。通过实验进一步证明RA患者中患有严重肿瘤与患有关节侵蚀两种不同病状的患者血清比较,CCP抗体水平差异非常显著(P<0.01)。结论抗CCP抗体对RA诊断具有很高的临床应用价值;并且抗CCP抗体与AKA、RF的三者联合检测有助于临床诊断和预后的判断。同时此方法操作简便,结果可靠,易于临床应用。更多还原

【Abstract】 Objective To discuss the clinical significance of combined determination of serum RF,AKA and anti-CCP antibody levels in aatients with rheumatoid arthritis.Method The serum RF,AKA and anti-CCP antibody of 137 patients with rheumatoid arthritis and 159 without rheumatoid arthritis were detected.Result The positive rate of the anti-CCP antibody was 98.2% in RA patients and 3.9% in non RA patients.The sensitivity and specificity of CCP,RA and AKA were 98.2% and 95.4%,i 49.1% and and 94.3% and 86% and 83%.The significant correlation were found between anti-CCP antibody and AKA,RF.Conclusion The combined determination of serum RF,AKA and anti-CCP antibody levels in patients with rheumatoid arthritis is helpful to the clinical diagnosis and prognosis judgment.更多还原