The deposition of insoluble β-amyloid(Aβ) is the key link of Alzheimer′s disease(AD).Aβ is produced by sequential proteolytic cleavage of the β-amyloid precursor protein(APP) by β-(BACE1) and γ-secretases.Aβ production is affected by the trafficking of BACE1 and APP among plasma membrane,endosome/lysosome,trans golgi network(TGN) and the early secretary pathways.Here this article used Western blot and immunofluorescence to investigate the effect of sorting nexin12(SNX12) on Aβ production and the underlying ...
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