【摘要】 目的探讨甲状腺激素、性激素与男性精神分裂症的关系及其可能的致病机制,为临床诊断和治疗提供参考依据。方法 73例精神分裂疾病患者为病例组;70例正常体检者为为对照组,采用化学发光法分别测定不同组别的甲状腺过氧化物酶抗体(a TPO)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)和睾酮(TSTO)、催乳素(PRL)、雌二醇(E2)的浓度;对病例组不同病程的激素水平进行分析;比较两组激素水平的异常率;分析病例组不同激素水平BPRS分值。结果精神分裂组的甲状腺激素浓度显著高于正常人,TSH明显低于正常人;性激素中的TSTO和PRL浓度显著高于正常人;大部分激素水平随着病程的延长而明显升高;多数被测激素的异常率较正常对照高;大部分激素水平异常患者的BPRS分值比激素水平正常患者高。结论甲状腺激素、性激素对男性精神分裂症的发生发展有一定的促进作用,能够为临床研究其致病机制提供帮助。更多还原

【Abstract】 Objective To investigate the relationship of thyroxin,sex hormones and male schizophrenia and the mechanism of it.To provide evidence for clinical diagnoise and therapy. Methods Serum anti-thyroid peroxidase（a TPO）,triio dothyronine（T₃）,thyroxine（T₄）,thyrotropic-stimulating hormone（TSH）,testosterone（TSTO）,prolactin（PRL）,estradiol（E2）levels were measured with chemiluminescence immunoassays in 73 male schizophrenia patients and 70 normal controls.All data were analyzed by SPSS. Results A TPO、T₃、T₄、TSTO、PRL levels were significantly higher in emotional disturbane patients than those in normal controls,while E2 was significantly lower.And TSH lies in a notable reduction. Conclusion There are significantly changes in thyroxin,sex hormones in male schizophrenia patients.Thyroxin and sex hormones may be the promoting agent for male schizophrenia.更多还原