【摘要】 目的探讨血清脂联素水平与慢性乙型肝炎、慢性丙型肝炎的相关性。方法选取98例乙型肝炎、丙型肝炎患者及病毒携带者作为观察组,根据每ml血清病毒含量分为:低病毒含量组(<1.0×104copies/ml)和高病毒含量组(≥1.0×104copies/ml)。选取50例肝功能正常者作为对照组,用ELISA方法测定两组的血清脂联素水平,并用全自动生化分析义对患者的AST和ALT进行检测,观察两组脂联素水平的差异,以及脂联素水平与AST/ALT比值的关系。结果对照组血清脂联素平均水平为5.12 g/ml,且女性的脂联素水平比男性高(p<0.01)。观察组慢性乙肝患者的脂联素水平比对照组低,但是统计结果无明显差异;慢性丙肝患者的脂联素水平与对照组也无统计学差异。乙型与丙型肝炎病毒携带者的脂联素水平比对照组高(p<0.01),同时观察组的女性脂联素水平也比男性高(p<0.01),观察组中慢性肝患者的AST和ALT比值与脂联素水平呈负相关。结论脂联素可以由损伤的肝细胞分泌,脂联素的水平与慢性病毒性肝炎患者的肝功能损伤程度有关。更多还原

【Abstract】 Objective To Discover the contact with Adiponectin and chronic viral hepatitis.Methods Select the 98 cases of hepatitis B,hepatitis C patients and HIV carriers as the observation group,Selected 98 patients with normal liver function as the control group,measured the serum adiponectin level by ELISA,and compare,to observe the differences in Adiponectin levels between the two groups.Results The Control group,the average serum level of adiponectin is 5.12 g/mL,and adiponectin levels in women is higher than men(p<0.01).Chronic hepatitis B patients in the observation group,adiponectin levels is lower than the control group,but no significant difference in results,chronic hepatitis C patients with adiponectin levels were also no significant statistical difference.Hepatitis B and hepatitis C virus carriers adiponectin levels than the control group(p<0.01),while the observation group adiponectin levels of women than men(p<0.05).Conclusion The adiponectin is Secreted by the damage liver cells,and the adiponectin levels in patients with chronic viral hepatitis is related with the liver injury.更多还原