【摘要】 [目的]探讨山莨菪碱对急性肺挫伤患者早期血清TNF-α、IL-6、IL-10的影响。[方法]选取60例急性肺挫伤患者随机分为山莨菪碱治疗组(治疗组)和常规治疗组(对照组),各30例。常规治疗组按常规方法治疗,治疗组在常规治疗基础上加用山莨菪碱1.0 mg.kg-1静推,3/d,连续应用2 d。两组患者治疗第24 h、48 h时抽取静脉血,检测血清TNF-α、IL-6、IL-10浓度。[结果]两组患者治疗后第24 h血清TNF-α、IL-6、IL-10水平,差异无统计学意义(P﹥0.05);治疗组治疗后第48 h血清TNF-α、IL-6水平明显低于对照组,IL-10水平明显高于对照组,差异有统计学意义(P﹤0.05)。[结论]山莨菪碱可抑制急性肺挫伤患者血清促炎细胞因子TNF-α、IL-6,升高抑炎细胞因子IL-10水平。山莨菪碱可能通过调节TNF-α、IL-6、IL-10,对急性肺挫伤患者产生保护作用。更多还原

【Abstract】 [Objective]To testify the effect of anisodamine on serum inflammatory cytokines in patients with acute pulmonary contusion(APC)at the early period.[Methods]All 60 patients with APC confirmed were randomly divided into the anisodamine therapy group(anisodamine group)and the routine therapy group(control group),each with 30 cases.Routine treatment was given to the control group.In the anisodamine group,patients were given anisodamine injection 1.0 mg·kg-1 by 3 times daily for 2 days plus the routine treatment.At the 24th and 48th hour after treatment,venous blood was sampled to detect serum TNF-α,IL-6,IL-10 concentrations.[Results]No difference of the serum TNF-α,IL-6,IL-10 concentrations was found between the two groups at the 24th hour(P﹥0.05).At the 48th hour after treatment,levels of TNF-α,IL-6 were obviously higher in the control group,while level of IL-10 was obviously highly in the anisodamine group(P﹤0.05).[Conclusion]Anisodamine could reduce the serum level of TNF-α,IL-6,but elevate IL-10 in patients with APC.Anisodamine may play a protective role in APC by regulating TNF-α,IL-6,IL-10.更多还原