【摘要】 [背景]代谢综合征(metabolicsyndrome,MS)所致慢性肾脏病(chronickidneydisease,CKD)发病率日益增高,预防性肾保护可以终止或逆转高危因素向肾损害方面的发生和发展。[目的]探讨补肾治疗对MS所致CKD患者肾损害及胰岛素抵抗的影响。设计、场所、对象和干预措施:纳入2008.7.1~2010.7.1在成都市第五人民医院住院及门诊患者,随机分为对照组和治疗组,治疗组在西医基础治疗的基础上加用六味地黄丸或金匮肾气丸,12周为1个疗程,共2疗程。[结果]研究发现1疗程结束后治疗组ACR、CRP(P﹤0.05)及金匮肾气丸组HOMA-IR(P=0.027)比较结果差异有统计学意义,2疗程结束后治疗组ACR、CRP及HOMA-IR(P﹤0.05)比较结果差异均有统计学意义。[结论]补肾疗法无论补肾阴或补肾阳,均可改善肾损害实验室指标或改善胰岛素抵抗,减轻体内炎性反应,不同程度改善脂代谢异常。更多还原

【Abstract】 [Objective]To investigate kidney-nourishing therapy on renal injury and insulin resistance of patients with CKD induced by MS.[Methods]Hospital inpatients and outpatients were accepted in Fifth People’s Hospital of Chengdu from July 1,2008 to July 1,2010,and they were randomly divided into control group and treatment group on the basis of western medicine.In the treatment group,Liuwei Dihuang Pill or Jinkui Shenqi Pill were added on the basis of western medicine treatment,12 weeks for a course of treatment.[Results]Compared with the control group,after the first time of therapy,ACR,CRP(P﹤0.05)and HOMA-IR(P= 0.027)of Jinkui Shenqi Pill cases were decreased significantly.After the second time of therapy,ACR,CRP and HOMA-IR(P﹤0.05)were all decreased significantly.[Conclusion]Kidney-nourishing therapy,regardless of invigorating kidney-yin or kidney-yang,can improve the laboratory indicators of renal injury or insulin resistance,reduce the inflammatory response in vivo,ameliorate disorder of lipid metabolism by various degrees.更多还原