【摘要】 [目的]探讨格拉司琼联合胃复安预防肿瘤化疗后恶心呕吐的疗效及安全性。[方法]选择在某院接受化疗的肿瘤患者90例,分成观察组和对照组。对照组采用胃复安联合地塞米松。观察组采用格拉司琼联合胃复安。[结果]观察组总有效率为93.33%高于对照组总有效率68.89%,差异有统计学意义(P﹤0.01)。观察组出现便秘发生率为22.22%与对照组24.44%相比较,差异无统计学意义(P﹥0.05);观察组的失眠发生率为11.11%与对照组8.89%相比较,差异无统计学意义(P﹥0.05)。[结论]应用格拉司琼联合胃复安用于肿瘤化疗后恶心呕吐具有显著的预防效果,副作用少,建议临床进一步推广应用。更多还原

【Abstract】 [Objective]To investigate the efficacy and safety of granisetron combined metoclopramide for the prevention of nausea and vomiting after cancer chemotherapy.[Methods]90 patients with cancer chemotherapy in our hospital were divided into observation group and control group.Control group was given with metoclopramide and dexamethasone.Observation group was given granisetron combined with metoclopramide.[Results]The total effective rate was 93.33% higher than the total effective rate was 68.89%,the difference was significant(P﹤0.01).Constipation occurred in observation group and control group,the incidence was 22.22% and 24.44%,the difference was not significant(P﹥0.05);the incidence of insomnia in the observation group was 11.11%,compared with that in the control group(8.89%),the difference was not significant(P﹥0.05).[Conclusion]Granisetron united metoclopramide for nausea and vomiting after chemotherapy has a significant preventive effect,less side effects,which to be recommended with further clinical application.更多还原