【摘要】 [目的]研究盐酸法舒地尔对急性脑梗死(ACI)患者血清S100B蛋白和超敏C反应蛋白(hs-CRP)水平的影响。[方法]选择某院2009.06～2010.12治疗的ACI患者106例,随机分为盐酸法舒地尔组56例,常规治疗组50例,常规治疗组给予常规治疗,盐酸法舒地尔组在此基础上给予盐酸法舒地尔,观察评价2组患者的血清S100B蛋白浓度变化、血清hs-cRP浓度变化、神经功能改善。[结果]2组总体病情均明显好转,差异有统计学意义。盐酸法舒地尔组与常规治疗组的血清S100B蛋白变化、血清hs-CRP变化、神经功能改善等比较差异均有统计学意义(P﹤0.05)。[结论]盐酸法舒地尔能明显降低ACl患者血清S100B蛋白和hs-CRP水平,并有助于ACI患者的神经功能恢复。更多还原

【Abstract】 [Objective]To study effects of fasudil on S-100B protein and high-sensitivity C-reactive protein in acute cerebral infarction patients.[Methods]A randomized double-blind study was designed to value effects of fasudil on acute cerebral infarction,with routine therapy as placebo-control group.One hundred and six patients were chosen from Jun 2009 to Dec 2010,which were divided into two groups:fasudil group(56 cases)and control group(50 cases).Serum levels of S100B protein,serum levels of hs-CRP,improvement of neurological function were observed.[Results]There were better clinical outcomes in the two groups,P﹤0.01.There was a significant difference between two groups.In fasudil group,serum levels of S100B protein,serum levels of hs-CRP,improvement of neurological function were markedly different compared with those in placebo-control group(P﹤0.05).[Conclusion]Fasudil can significantly decrease the level of S100B protein and hs-CRP,and improve the neurological function of cerebral infarction patients.更多还原