【摘要】 [目的]通过临床研究,探讨青年缺血性脑血管病的病因及其干预措施。[方法]选取112例青年缺血性脑血管病患者,随机分为B、C两组,每组56例。选取50例健康体检人员为A组。B、C组均针对糖尿病、高血压、心脏病等原发基础疾病给予相应治疗;C组在治疗原发病的基础上给予阿托伐他汀治疗;A组未给予任何治疗。检测患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDLC)、低密度脂蛋白(LDLC)、动脉粥样硬化斑块性质及数目、颈动脉内中膜厚度(IMT)、峰值流速(PV)及阻力指数(RI)。[结果]与A组比较,B组TC、TG、LDLC水平及IMT值明显升高(P﹤0.05),HDLC水平、SPV值明显降低(P﹤0.05),且其斑块检出数明显增多(P﹤0.05);而与B组比较,C组TC、LDLC水平及IMT值明显降低(P﹤0.05),HDLC水平及SPV值明显升高(P﹤0.05),且其斑块检出数较较未使用者有减少趋势。[结论]颈动脉粥样硬化是青年型缺血性脑血管病的重要致病因素之一,他汀类药物对其有干预治疗作用。更多还原

【Abstract】 [Objective]To study the youth ischemic cerebrovascular pathogenesis and its intervention measures by clinical research.[Methods]We selected 112 patients of youth ischemic cerebrovascular disease who were randomly divided into B and C groups,and selected 50 healthy persons as the group A. B and C group were given corresponding treatment for diabetes,high blood pressure,heart disease and other primary basic diseases. At the same time,C group were given atorvastatin treatment,and A group were not given any treatment. The total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDLC),low density lipoprotein(LDLC),atherosclerotic plaque properties and number,the carotid intima-media thickness(IMT),peak flow(PV)and resistance index(RI)were detected.[Results]Compared with the group A,the TC and TG,LDLC and IMT of B group significantly increased(P﹤0.05),and HDLC level,SPV decreased obviously(P﹤0.05),and the plaques number increased(P﹤0.05). Compared with group B,the TC,LDLC and IMT of C group decreased obviously(P﹤0.05),and HDLC and SPV increased(P﹤0.05),and the plaques number was tested on decreasing trend.[Conclusion]Carotid atherosclerosis is one of the important ischemic cerebrovascular pathogenesis in youth,and statins is one of the intervention treatment.更多还原