【摘要】 [目的]了解小儿慢性EB病毒感染的临床表现及多系统损害情况,以提高临床诊治水平。[方法]对经临床确诊的15例慢性EB病毒感染患儿的临床表现、诊断及预后进行回顾性分析。[结果]显示临床表现多种多样,常出现严重或致死性的并发症,病例中有7例死亡,死亡率为46.7%,另有多例留下严重后遗症。[结论]慢性活动性EB病毒感染是一种预后不良的全身性感染,病死率较高,其中因脏器功能不全而死亡的病例约占半数,临床缺乏规范而有效的治疗方案。因此,输注自体EBV特异性细胞毒T淋巴细胞或异基因造血干细胞移植应有较好的治疗前景。更多还原

【Abstract】 [Objective]To explore the chronic EB virus infection in children with clinical manifestations and multi-system damage,so as to improve the clinical diagnosis and therapy.[Methods]The clinical manifestations,diagnosis and prognosis of 15 clinically diagnosed children with chronic EB virus infection were retrospective analyzed.[Results]Cases showed variety of clinical manifestations,such as severe or fatal complications,with a mortality rate of 46.7%(7 cases),while several cases had serious sequelae.[Conclusion]Chronic active EB virus infection is a systemic infection of poor prognosis with high mortality,including deaths due to organ dysfunction accounts for about half of the cases. Since the lack of standardized treatment and effective treatment programs,infusion of autologous EBV-specific cytotoxic T lymphocytes or allogeneic hematopoietic stem cell transplantation should be a promising treatment.更多还原