【摘要】 [目的]观察辛伐他汀和缬沙坦合用在轻中度原发性高血压患者的长期治疗过程中的临床疗效和安全性。[方法]103例轻中度原发性高血压病患者均是来自我院门诊病例,通过记录的随机号数字表产生分组随机号,分为治疗组53例,对照组50例,治疗组缬沙坦和辛伐他汀合用,对照组缬沙坦单用,用药10周后进行疗效分析。[结果]治疗组总有效率达97.1%,对照组总有效率84.0%,两组间疗效差异有统计学意义(P﹤0.05)。两组治疗后较治疗前比较偶测血压、24h、日间、夜间平均血压均下降(P﹤0.01),TC和LDL-C降低(P﹤0.05)。治疗组和对照组治疗后比较,偶测血压、24h、日间、夜间平均血压亦均下降(P﹤0.05),谷/峰比值也优于对照组(P﹤0.05)。[结论]他汀类药物在高血压患者的长期治疗过程中具有有效降低血压的作用,特别对高血压合并高血脂的患者是理想的用药选择。更多还原

【Abstract】 [Objective] To observe the clinical therapeutic effect and safety of Simvastatin combined with Valsartan in the long-term treatment of slight and midrange essential hypertension.[Methods]103 patients with slight and midrange essential hypertension were divided randomly into treatment group(n=53)and control group(n=50).And the treatment group was treated with Simvastatin and Valsartan,while the control group was treated only with Valsartan.The effect was analyzed after 10 weeks.[Results]The overall effective rate in treatment group was 97.1% and control group was 84.0%,the effect difference of two groups had statistical significance(P﹤0.05).Before and after treatment,the clinical blood pressure and the averaged blood pressure during 24-hour,daytime and nighttime of two groups were reduced(P﹤0.01),and the TC and LDL-C were reduced(P﹤0.05)too.Compared with treatment group and control group after treatment,the clinical blood pressure and the averaged blood pressure during 24-hour,daytime and nighttime of two groups were reduced(P﹤0.05),the ratio of valley and peak in the treatment group was superior to the control group.[Conclusion]It is effective to reduce the blood pressure in treating hypertension with statins,especially it is the best choice to the hypertensive patients with hyperlipemia.更多还原