【摘要】 [目的]评价拉西地平联合缓释型硝苯啶治疗高血压的临床疗效。[方法]选择本院入院高血压病人共158人,随机分为缓释型硝苯啶组78名和拉西地平联合缓释型硝苯啶组80名。治疗6个月,收集病人的舒张压(DBP)、收缩压(SBP)、心率、肱动脉充血后内径变化率(FMD)、舒张末期颈总动脉内中层厚度(IMTcca)、冠状动脉分叉中层厚度(IMTbif)、颈内动脉中层厚度(IMTica)、舒张末室间隔厚度(LVST)、左室后壁厚度(LVPWT)、左室舒张末内径(LVID)、左室质量指数(LVMI)、超敏C反应蛋白(hs-CRP),并比较两组差异。[结果]临床试验显示,拉西地平联用组平均收缩压由给药前的159.4mmHg降至127.1mmHg,平均舒张压由99.7mmHg降至78.4mmHg(P﹤0.05)。拉西地平联用组的3个IMT,即IMTcca、IMTbif、IMTica和给药前比均有不同程度的降低(P﹤0.05),而缓释型硝苯啶组以上3个指标有降低趋势,但差异无统计学意义(P﹥0.05)。与缓释型硝苯啶组比,拉西地平联用组的PWTD、LVID、LVMI均有明显改善(P﹤0.05),hs-CRP显著降低(P﹤0.05)。[结论]拉西地平联用组具有显著地降低血压,增加心脏容量,并同时减轻左室肥厚,减少高血压病人炎症的作用。更多还原

【Abstract】 [Objective] To evaluate the effects of the lacidipine combined extended release nifedipine on hypertensive patients.[Methods]158 cases of hypertensive patients were collected in our hospital,and were divided into extended release nifedipine group,lacidipine and extended release nifedipine group.The duration of treatment was 6 months.Diastolic blood pressure(DBP),systolic blood pressure(SBP),heart rate(HR),intima-media thickness of the common carotid artery(IMTcca),IMT of the bifurcating coronary artery(IMTbif),IMT of the internal carotid artery(IMTica),left ventricular spetum thickness(LVST),left ventricular end-diastolic posterior wall thickness(LVPWT),LV internal diameter (LVID),left ventricular mass index(LVMI),flow-mediated brachial artery dilation(FMD),high-sensitivity C-reactive protein(hs-CRP)were observed in all patients.[Results]Six months medical treatment revealed that SBP of lacidipine and extended release nifedipine group was significantly diminished from 159.4 mmHg to 127.1 mmHg,and that of Extended Release Nifedipine group was down from 99.7 mmHg to 78.4mmHg(P﹤0.05).The levels of IMTs of the lacidipine and extended release nifedipine group were significantly lower.However,whereas the IMTs of Extended Release Nifedipine group did not show any significant changes(P﹥0.05).Compared with extended release nifedipine group,the hs-CRP was also lower.Lacidipine and extended release nifedipine group significantly improved the condition of heart.[Conclusion]lacidipine and extended release nifedipine group leads to a significant reduction of BP of patients with hypertension as well as to a decrease in markers of inflammation during a relatively short period(6 months).更多还原