【摘要】 [目的]探讨不同免疫阻断方式对HBV母婴传播的阻断作用。[方法]以HBsAg阳性孕妇及其婴儿为对象,按不同阻断方式分组,A组126例采用对孕晚期孕妇及其新生儿注射乙肝免疫球蛋白(HBIG),同时对新生儿联合采用乙肝疫苗注射;B组102例仅新生儿联合使用HBIG及乙肝疫苗注射;C组215例只对新生儿进行乙肝疫苗接种作为对照。检测分析A组孕妇使用HBIG前后血液HBV-DNA含量变化,比较各组新生儿出生后的宫内感染率及1岁后感染率。[结果]A组孕妇使用HBIG前后血液HBV-DNA含量差异无统计学意义,A、B、C3组宫内感染率分别为4.76(6/126)、4.92(5/102)和4.65(10/215),差异无统计学意义,1年后感染率分别为5.92、4.93、8.3,C组HBV感染率与A、B组比较差异有统计学意义(P﹤0.05)。[结论]孕期使用乙肝免疫球蛋白不能降低孕妇病毒载量,对HBV宫内传播也无保护作用。对新生儿联合使用HBIG及乙肝疫苗注射与单纯接种乙肝疫苗相比,能减低HBV感染率。更多还原

【Abstract】 [Objective]To investigate the effect of different immunization methods on interrupting maternal-infant vertical transmission of hepatitis B virus.[Methods]HBsAg positive of pregnant women and infants were divided into three groups.In group A(126 cases),pregnant women and the infants were injected with hepatitis B immunoglobulin(HBIG)during pregnancy since the 28th week of gestation and HBVac was injected to their infants,while in group B(102 cases)pregnant women were not injected with HBIG.In the control group C(215 cases),the infant were injected with HBVac only.HBV DNA in maternal sera of group A was detected and the copies before injection with after injection were compared.The incidence of HBV intrauterine transmission was compared and incidence of HBV infection in 1 the year infant in 3 groups.[Results]The difference was not significant between before injection and after injection in group A(pregnant women).Incidence of HBV intrauterine transmission was 4.76%(6/126)in group A,4.92%(5/102)in group B and 4.65%(10/215)in group C and there was significant difference in the three groups.Incidence of HBV infection in the A and B was significantly lower than that of C in one year infants(5.92% in A,4.93% in B vs 8.3% in C,P﹤0.05).[Conclusion]HBIG administration during pregnancy didn’t decrease copies of HBV DNA,and the protective effect on HBV intrauterine infection was not found..combining HBIG with HBVac can decrease incidence of HBV infection in infants.更多还原