【摘要】 [目的]通过对食管癌术后患者生存分析,了解影响该病预后的相关因素,为临床的诊治及防治提供参考依据。[方法]收集经手术病理确诊710例食管癌病例的基本信息、危险因素、家族史、手术记录、术后病理报告、随访资料等相关信息。采用kaplan-meier法和Cox回归分析计算生存率,绘制生存曲线,对预后相关因素进行筛选和评价。[结果]食管癌术后患者1年、3年、5年生存率分别为:78.4%、56.9%、27.0%,中位生存期为900d。单因素分析结果显示,影响预后的独立因素是:病理形态、肿瘤大小、分化程度、侵犯层次、切缘、淋巴结是否转移、转移数量、手术方式与预后有关。多因素分析结果显示,淋巴结转移、侵犯层次、手术方式、肿瘤部位、肿瘤大小、分化程度与食管癌预后有关。[结论]食管癌术后5年生存率仍较低,临床分期是食管癌术后影响预后的重要因素。临床分期较早的病例术后预后较好,生存率较高。早期诊断、早期治疗仍是降低食管癌死亡率的主要手段。更多还原

【Abstract】 [Objective]To analyze the patients’ postoperative survival who have suffered the esophageal cancer,and the related factors that influence the prognosis could be learned in order to provide the reference to the clinical diagnosis,treatment and prevention.[Methods]The related information of the basic message,risk factors,family history,surgery records,pathological reports after the operation and follow-up visit data of the 710 cases who had been confirmed as the esophageal cancer pathologically were collected.Used Kaplan-Meier and Cox model to calculate the survival rate,draw survival curve,screen and evaluate the prognostic factors.[Results]The survival at the 1st,3rd,5th year was 78.4%,56.9%,27.0% respectively and median survival was 900 days.In univariate analysis,independent factors were linked with survival which included:pathology shape,size of tumor,depth of invasion,differentiation of tumor,cut margin,node metastases,number of node metastases and cure methods.In multivariate analysis,6 factors were linked with survival which included:node metastases,differentiation of tumor,cure methods,size of tumor and depth of invasion.[Conclusion]The survival at the 5th year is still low.Clinical stage is the major prognostic factor affecting the survival of patients with esophageal carcinoma.The patient who has been staged clinically earlier would have better prognosis and higher survival rate.Early diagnosis and treatment are still the main means to lower mortality.更多还原