【摘要】 肺纤维化是多种原因引起的慢性肺疾病的共同结局,其病变特点是肺部炎症导致肺泡持续性损伤、反复破坏、修复、重建及细胞外基质的过度沉积。肿瘤坏死因子α(TNF-α)是一种细胞毒因子,在肺纤维化的发病机制中起着关键作用。近年的研究表明,TNF-α可通过激活NF-κB信号通路,在肺纤维化的形成过程中发挥作用。现对TNF-α介导的NF-KB信号通路在肺纤维化中的作用作一综述。更多还原

【Abstract】 Pulmonary fibrosis is the common outcome of chronic lung diseases caused by a variety of reasons,and is characterized by pulmonary inflammation,leading to persistent damage,repeated damage,repair,reconstruction,and excessive extracellular matrix deposition.Tumor necrosis factor-α(TNF-α)is a cytotoxic factor,playing a key role in the pathogenesis of pulmonary fibrosis.Recent studies show that TNF-α plays a role in activating NF-κB signaling pathway in pulmonary fibrosis.Role of tumor necrosis factor-αsignaling pathway mediated by nuclear factor kappa B in pulmonary fibrosis is reviewed.更多还原