【摘要】 [目的]探讨IL-6基因-572C/G多态性与唐山地区汉族人群脑梗死易感性的关系。[方法]应用聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)方法测定唐山地区汉族人群中157例脑梗死患者及163例健康对照人群IL-6基因-572C/G的基因分型和遗传易感性分析。[结果]脑梗死组IL-6-572C/G基因型的分布频率与对照组比较差异有统计学意义(P﹥0.05),等位基因频率在两组中也存在统计学差异(P﹤0.05)。等位基因频率的相对风险分析,G等位基因携带者发生脑梗死的风险是C等位基因的1.815倍(R=1.815,95CI:1.305～2.149)。收缩压、舒张压、FBS、LDL、Fg、-572G是唐山地区汉族人群脑梗死发生的独立危险因子(OR值分别为3.95、4.07、6.46、49.12、2.93、6.59)。[结论]IL-6基因-572C/G多态性可能与脑梗死有关,-572G等位基因可能是脑梗死发病的易感基因。更多还原

【Abstract】 [Objective]To study the relationship of IL-6 gene promoter-572C/G Polymorphism and the hereditary susceptibility of cerebral infarction in Han population of Tangshan area.[Methods]The IL-6 gene promoter-572C/G polymorphism were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)analysis among 157 patients with cerebral infarction and 163 cases with healthy controls.[Results]There was significant difference in frequencies of allele and genotype in-572C/G polymorphism between cerebral infarction and control groups respectively(P﹤0.05).The relative risk suffered from cerebralinfarction of C allele was 1.815 times of the G allele(R=1.815,95 CI:1.305-2.149).Logistic regression analysis revealed systolic pressure,diastolic pressure FBS,LDL,Fg and-572G were the independent risk factors of cerebral infarction in Han population of Tangshan area.[Conclusion]IL-6 gene promoter-572C/G polymorphism was associated with cerebral infarction,and G allele may be a genetic risk factor of cerebral infarction.更多还原