【摘要】 背景:以组织工程骨为骨源修复颅颌部骨缺损不仅解决临床骨源缺乏的问题,还促进组织工程骨的培养及基因导入疗法修复骨缺损等方面的研究。目的:总结归纳有关颅颌面部骨缺损修复中的相关因子,介绍目前此类因子的研究进展与方向。为组织工程骨及基因治疗修复颅颌面部骨缺损提供依据及参考。方法:以"tissue engineering,bone defect,gene therapy,growth factor"为检索词,检索Pubmed数据库(2000-01/2011-01),以"组织工程学,骨缺损,基因治疗,生长因子"为检索词,检索CBM数据库(2000-01/2011-01)。文献检索语种为英文和中文。纳入颅颌面部骨缺损修复过程中有关因子的文献,排除重复文献。结果与结论:计算机初检得到670篇文献,根据纳入排除标准,对其中33篇文献进行分析。由于各种原因引起的颅颌部骨缺损在临床上逐渐增多,而骨源缺乏是制约颅颌部骨缺损的主要问题。体外构建组织工程骨是解决这一问题的主要途径。颅颌面骨形成和发生的过程涉及因子的选取,组织工程骨的构建等方面,多基因联合治疗是目前的发展趋势。更多还原

【Abstract】 BACKGROUND:Repairing cranial and maxillofacial bone defect with tissue-engineered bone can solve the problem of lacking bone source and promote the culture of tissue-engineered bone and assist in repairing bone defects using gene therapy.OBJECTIVE:To summarize the related factors of cranial and maxillofacial bone defect repair and introduce the research progress in this type of factors,providing reference evidence for repairing cranial and maxillofacial bone defect using tissue-engineered METHODS:Taking "tissue engineering,bone defect,gene therapy,growth factor" as ,a computer-based online retrieval was performed to search papers published between January 2000 and January 2011 in PubMed and CBM databases in English and Chinese.Papers regarding related factors of cranial and maxillofacial bone defect repair were included and papers with repeated contents were excluded.RESULTS AND CONCLUSION:A total of 670 papers were initially retrieved.According to inclusion and exclusion criteria,33 papers were included in the final analysis.There are more and more causes for cranial and maxillofacial bone defects and lacking bone source is a primary problem of restricting cranial and maxillofacial bone defect repair.In vitro construction of tissue-engineered bone is a primary method for solving this problem.Cranial and maxillofacial bone formation involves selection of related factors and construction of tissue-engineered bone,and multi-gene therapy is a promising method.更多还原