【摘要】 背景:骨组织形态计量学是一种定量的不脱钙骨组织学切片检查,能取得骨重建和结构的定量信息。近年来已广泛应用于代谢性骨病发生发展机制、抗骨质疏松症药物等研究。目的:从骨组织形态计量学被认识到临床研究、临床应用以及展望进行综述。方法:由第一作者分别以"骨组织形态计量学,骨活检,代谢性骨病,骨重建,骨结构,人"和"Bone histomorphometry,metabolic bone diseases,bone biopsy,bone remodeling,humans"为关键词进行检索,CNKI数据库的检索时限为2000/2010,PubMed数据库的检索时限为1965/2010。筛选骨组织形态计量学方面的文献,最终纳入30篇文献进行分析。结果与结论:骨计量学可得到三维的骨结构和重建的参数,在评估、提供骨代谢信息方面是一个功能强大的工具,其他任何研究方法不可代替。对于各种各样的骨代谢疾病,可从骨计量学方面更深层了解骨病的发生发展机制,为治疗提供更可靠的依据。此外,在临床新的药物安全干预、研究试验中,它提供了宝贵的骨结构和重建的参数资料。更多还原

【Abstract】 BACKGROUND:Bone histomorphometry is a quantitative histological examination of an undecalcified bone biopsy performed to obtain quantitative information on bone remodeling and structure.It has been widely used in the development of mechanisms in metabolic bone disease,anti-osteoporosis drugs and other research in recent years.OBJECTIVE:To review bone histomorphometry from it was aware of clinical research to clinical applications and prospects,to clarify its application and research status in clinical bone diseases.METHODS:A computer of CNKI database(2000-2010) and PubMed database(1965-2010) was performed by the first author using "bone histomorphometry,metabolic bone diseases,bone biopsy,bone remodeling,humans" in Chinese and English as the key words,to retrieve relevant literatures about the research of bone histomorphometry in clinical bone disease,Finally,30 literatures were included for analysis.RESULTS AND CONCLUSION:The results show that the bone histomorphometry is of indispensable value and significance in clinical use and effective assessment.Bone histomorphometry has an important role in bone structure,bone metabolism,bone biology pathology,bone and bone-reactive protein and other drugs in several directions,multidisciplinary research.更多还原