【摘要】 背景:尽管作为植入材料镁具有良好的生物相容性及可降解吸收等优点,但镁腐蚀过快,它的快速腐蚀将引起其机械性能在骨组织康复之前就显著下降。目的:检测纯镁及微弧氧化、二水磷酸氢钙涂层后的纯镁的血液相容性。方法:将纯镁及微弧氧化、二水磷酸氢钙两种涂层后的纯镁浸提液与抗凝稀释兔血接触,阴性对照组用为生理盐水,阳性对照为蒸馏水。混匀后离心,用分光光度计测定其上清液的A值,计算溶血率。结果与结论:未经处理的纯镁浸提液组溶血率为52.34%,微弧氧化涂层后的纯镁浸提液组溶血率为0.32%,二水磷酸氢钙涂层后的纯镁浸提液组溶血率为0.14%,阴性对照组溶血率为0,阳性对照组溶血率为100%。提示未经处理的纯镁出现了较严重的溶血现象,涂层后的纯镁血液相容性良好,溶血率小于5%,符合国家标准。更多还原

【Abstract】 BACKGROUND:Although magnesium as implant material which has good biocompatibility and biodegradable absorption. However,excessive corrosion of magnesium will cause rapid decrease of the mechanical properties before rehabilitation of bone tissue. OBJECTIVE:To detect the blood-compatibility of pure magnesium(MG) ,micro-arc oxidized magnesium(MAO) and dicalcium phosphate dihydrate coating formed on micro-arc oxidized magnesium(DCPD) . METHODS:MG,MAO and DCPD extracts were contacted with anticoagulation dilution rabbit blood. Sodium Chloride was used in negative control group;distilled water was used in positive control group. Centrifuged after mixing,the optical density value of supernatant was determined by spectrophotometer,and hemolytic rate was counted. RESULTS AND CONCLUSION:Hemolytic rate of untreated pure magnesium extract group was 52.34%;the MAO and DCPDC extract group were 0.32% and 0.14%. Hemolytic rate of negative and positive group were 0% and 100%. The untreated pure magnesium showed a serious hemolysis. However,MAO and DCPD have excellent blood-compatibility,hemolytic rate is less than 5%,and they conform to the national standard requirement.更多还原