【摘要】 背景:有研究表明胰岛素样生长因子Ⅰ降低是骨丢失的早期标志。目的:测定大鼠牙槽骨组织中胰岛素样生长因子Ⅰ的活性,探讨丹参素防治牙槽骨骨质疏松症的可能机制。方法:SD大鼠随机分为对照组、去卵巢组和丹参素组,后两组行双侧卵巢切除,对照组和去卵巢组用蒸馏水灌胃,丹参素组用丹参素12.5mg/(kg?d)灌胃。给药90d后取大鼠牙槽骨,检测牙槽骨量、牙槽骨组织中胰岛素样生长因子Ⅰ活性。结果与结论:与对照组相比,去卵巢组骨小梁面积百分数减少33.88%(P<0.05),骨小梁分离度增加43.58%(P<0.05),牙槽骨骨量明显减少,牙槽骨组织中胰岛素样生长因子Ⅰ表达变少、变弱(P<0.05)。与去卵巢组相比,丹参素组骨小梁面积百分数增加了45.45%(P<0.05),牙槽骨骨量明显增多,牙槽骨组织中胰岛素样生长因子Ⅰ表达增强(P<0.05)。结果证实,丹参素能促进牙槽骨组织胰岛素样生长因子Ⅰ活性,防止去卵巢大鼠牙槽骨的丢失。更多还原

【Abstract】 BACKGROUND:Decrease in insulin-like growth factor 1(IGF-1)is an early marker of bone loss.OBJECTIVE:To determine the activity of IGF-1 in rat alveoar bone tissue and investigate the possible mechanism by which tanshinol prevents alveolar bone osteoporosis.METHODS:Twenty-four Sprague-Dawley rats were randomly divided into three groups:sham-ovariectomized rats,ovariectomized rats and ovariectomized rats with tanshinol treatment(12.5 mg/kg per day).At 90 days after administration,alveolar bone tissue was taken for detection of bone mass and the activity of IGF-1 in alveolar bone tissue.RESULTS AND CONCLUSION:Compared with sham-ovariectomized rats,alveolar bone mass was decreased significantly,percentage of trabecular bone was decreased by 33.88%(P < 0.05),trabecular separation was increased by 43.58%(P < 0.05)and IGF-1 expression was markedly decreased(P < 0.05)in ovariectomized rats.Compared with ovariectomized rats,alveoar bone mass was increased significantly,percentage of trabecular bone was increased by 45.45%(P < 0.05)and IGF-1 expression was markedly increased(P < 0.05)in ovariectomized rats with tanshinol treatment.These findings confirm that tanshinol can increase the expression of IGF-1 in alveolar bone tissue and prevent alveoar bone osteoporosis.更多还原