【摘要】 背景:骨骼肌的兴奋收缩偶联机制及快速、有效的兴奋收缩偶联直接决定了运动能力。三联管是骨骼肌中特有的结构,是兴奋收缩偶联的结构基础。位于三联管上的膜蛋白在三联管结构的发育、正常形态的维持和功能的发挥中均起着关键作用。目的:介绍三联管膜蛋白的研究进展,对双氢吡啶受体蛋白,兰诺定受体蛋白,MG29蛋白,JP蛋白,Calumin与STIM1蛋白,隐钙素和TRIC通道蛋白等的结构和功能进行了归纳总结。方法:电子检索中国学术期刊数据库CNKI、读秀学术搜索等中文数据库和Elsevier SD,Springer Link等英文数据库,检索时间1980/2010,均为骨骼肌衰老与力量—速度关系的相关综述和实验研究。并分析骨骼肌力量—速度关系随年龄变化的规律,以及该变化对老龄肌肉产生的影响。结果与结论:共纳入骨骼肌兴奋收缩偶联机制和三联管膜蛋白的相关文献28篇。归纳文献结论证明,位于骨骼肌三联管的双氢吡啶受体蛋白,兰诺定受体蛋白,MG29蛋白,JP蛋白,Calumin与STIM1蛋白,隐钙素和TRIC通道蛋白在骨骼肌的兴奋收缩偶联过程中各司其职,对骨骼肌正常的功能的发挥起着不可或缺的作用。但目前对这些蛋白的认识明显不足,尚需深入研究。更多还原

【Abstract】 BACKGROUND:The mechanism of excitation-contraction coupling (E-C coupling) in skeletal muscles and a fast and responsive E-C coupling mechanism directly determine the motor ability.The triad junction,which is the specific structure in skeletal muscles,is the infrastructures of E-C coupling.The membrane proteins in the triads play a key role in the development of the triads,maintaining the normal structural form of the triads and exerting the triadic full functions.OBJECTIVE:To review the research advances of triadic membrane proteins and to summarize the structure and functions of dihydropyridine receptor (DHPR),ryanodine receptor,MG29 protein,JP protein,Calumin and STIM1 protein,calsequestrin and TRIC.METHODS:Papers regarding skeletal muscle senescence and power-velocity were searched by computer in databases of CNKI,Duxiu,Elsevier SD and Springer Link from 1980 to 2010.The change laws of skeletal muscle power-velocity with aging and effect of this law on muscle was analyzed.RESULTS AND CONCLUSION:Totally 28 documents were included in this paper.Literature summary showed that,DHPR,ryanodine receptor,MG29 protein,JP protein,Calumin and STIM1 protein,calsequestrin and TRIC doing its own job in skeletal muscles,all of them play an indispensable role in maintaining normal function of skeletal muscles.However,the study of these proteins remains limited,which need further exploration.更多还原