【摘要】 背景:早幼粒细胞白血病蛋白的各异构体因C末端结构域序列不同而不同,但各异构体的作用尚不清楚。目的:回顾性分析早幼粒细胞白血病蛋白异构体在基因转录调控、细胞生长分化、细胞凋亡、免疫反应及其核体形成等方面的功能特点。方法:由第一作者检索1992/2010PubMed数据库和FMJS数据库有关野生型早幼粒细胞白血病蛋白、早幼粒细胞白血病蛋白核体结构、功能及早幼粒细胞白血病蛋白异构体的结构、命名、功能和3者之间联系等方面的文献。结果与结论:早幼粒细胞白血病基因是通过多种不同的mRNA剪接本来表达的,其中每一个剪接本都编码不同的蛋白即早幼粒细胞白血病蛋白异构体。由于各种蛋白异构体都拥有共同的N末端结构区域,从而决定其具有某些功能上的共性如细胞凋亡。而不同的C末端结构区域又决定它们具有各自功能上的特性如抗病毒、细胞生长分化作用。在未来的研究中需要进一步探索各种异构体功能作用的具体生物化学机制。更多还原

【Abstract】 BACKGROUND:Each isomer of promyelocytic leukemia protein is various due to different structural domain sequence at C terminal,but the effects of each isomer remain unclear. OBJECTIVE:To retrospectively analyze the genetic transcription regulation,cell growth differentiation,cell apoptosis,immune reaction and its karyosome formation of promyelocytic leukemia protein isomer. METHODS:The first author retrieved PubMed Database and FMJS Database for articles concerning wildtype promyelocytic leukemia protein,promyelocytic leukemia protein karyoplast,function as well as structure,naming and function of promyelocytic leukemia protein isomer and their interaction published from 1992 to 2010. RESULTS AND CONCLUSION:Promyelocytic leukemia protein gene was expressed as potentially many alternatively spliced mRNAs,each of which encodes a distinct protein i.e. promyelocytic leukemia protein isoform. As each promyelocytic leukemia protein isoform shares an identical N-terminal region,which decides they have general character in certain function,such as cell apoptosis. However,all isoforms of promyelocytic leukemia protein differ from one another by C-terminal domain,which decides that each promyelocytic leukemia protein isoform has respective character in certain function,such as intrinsic antiviral activities,cell growth and differentiation. Further studies will be required to explore the concrete biochemistry mechanism of the function of varied isoforms.更多还原