【摘要】 目的了解浙江平湖地区2型糖尿病(T2DM)患者非糖尿病一级亲属(FDR)常见中医体质类型血脂代谢状况。方法采用《中医体质分类研究》问卷对符合纳入标准的T2DM患者父母、子女或同胞兄妹进行方便抽样横断面现场调查,并以5∶1比例随机抽样抽血测定空腹12 h以上TC、TG、HDL-C、LDL-C、血尿酸(SUA)、游离脂肪酸(FFA)、超敏C反应蛋白(hs-CRP)等。结果该地区T2DM患者FDR体质类型以平和质、气虚质、阴虚质、痰湿质、气虚兼阴虚质及气虚兼痰湿质为常见;痰湿质及气虚兼痰湿质组TG水平分别与其他组比较均有显著性差异,气虚质、痰湿质及气虚兼痰湿质组HDL-C水平分别与平和质、阴虚质及气虚兼阴虚质组比较均有显著性差异,痰湿质及气虚兼痰湿质组SUA、FFA水平分别与阴虚质组比较均有显著性差异,气虚兼阴虚质与气虚兼痰湿质组SUA水平比较有显著性差异;气虚兼痰湿质组hs-CRP水平与平和质组比较有显著性差异。结论浙江平湖地区T2DM患者FDR中医体质以偏颇及兼夹体质类型为主,且不同体质类型群体血脂、SUA及慢性炎症状态存在差异,气虚兼痰湿质人群T2DM发病风险最大。更多还原

【Abstract】 Objective It is to know the state of lipid metabolism of common TCM constitution types of type 2 diabetes mellitus(T2DM) patients’ nondiabetic first degree relative(FDR) in Pinghu region of Zhejiang Province.Methods Adopting "Classifying study about body constitutions of traditional Chinese medicine" questionnaire,the convenient sample drawing method of field investigation at cross section was used to investigate T2DM patients’ parents,sons and daughters and siblings who consistent with the internalizing standard.In addition,blood after empty stomach above 12 h were randomly collected to determine TC,TG,HDL-C,LDL-C,SUA,FFA and hs-CRP according to proportion of 5∶ 1.Results It is the common body constitution types that mildly constitution,Qi deficiency constitution,Yin deficiency constitution,phlegmatic hygrosis constitution,Qi-Yin deficiency constitution,Qi deficiency combined with phlegmatic hygrosis constitution in FDR of T2DM patients in this region.Compared with the other groups,the levels of TG in phlegmatic hygrosis constitution group and Qi deficiency combined with phlegmatic hygrosis constitution group were significant.Compared with that in mildly constitution,Yin deficiency constitution,Qi-Yin deficiency constitution groups,the levels of HDL-C in Qi deficiency constitution,phlegmatic hygrosis constitution,Qi deficiency combined with phlegmatic hygrosis constitution groups were significant.There were significant differences in SUA and FFA levels between Yin deficiency group and phlegmatic hygrosis constitution,Qi deficiency combined with phlegmatic hygrosis constitution groups.There was significant difference in SUA level between Qi-Yin deficiency group and Qi deficiency combined with phlegmatic hygrosis constitution group.Compared with Qi deficiency combined with phlegmatic hygrosis constitution group,the level of hs-CRP was significant in mildly constitution group.Conclusion It is the feature that the common body constitution types of TCM are all of partial and combining constitutions to FDR of T2DM patients in Pinghu region in Zhejiang Province.Furthermore,the differences of lipid metabolism,SUA and chronic inflammation symptom are significant among the different body constitution types.The ones with Qi deficiency combined with phlegmatic hygrosis constitution have the largest onset risk to face with T2DM.更多还原