【摘要】 脂肪因子是由脂肪组织分泌的肽类物质,影响着整个机体的能量代谢,在多种病理过程中起着关键性调节作用。PBEF/Nampt/Visfatin是2005日本学者新发现的一种脂肪因子,由于其具有类胰岛素作用而成为研究热点。目前对该因子属性、作用及作用机制的探讨十分激烈。尽管对PBEF/Nampt/Visfatin的认识尚未明了,但其在代谢性疾病中的作用为该类疾病的病理机制做了重要补充,并且为攻克这类疾病提供了新思路、新靶点。更多还原

【Abstract】 Adipokines are bioactive peptides,secreted by adipose tissue,which are considered to be important factors of metabolism.PBEF/Visfatin/Nampt has been proposed to be a novel adipokine with insulin mimetic effect in 2005.Although the precise mechanisms underlying the beneficial effects on insulin sensitivity remain unknown,understanding this new exciting world of adipocytokines will be of importance in the development of novel therapeutic approaches for obesity-related disorders.更多还原