【摘要】 目的:探讨无创正压通气(NPPV)在高海拔地区治疗重症支气管哮喘的有效及安全性。方法:68例重症支气管哮喘患者随机分为治疗组(NPPV组)37例,对照组(non-NPPV组)31例;治疗组在常规治疗基础上加NPPV,对照组常规治疗。结果:治疗2 d后两组患者的呼吸频率(RR)、心率(HR)、动脉血pH、PaO2、PaC02、SaO2均有明显改善(P<0.01);治疗组在治疗24 h和3 d后pH、PaO2、PaC02、SaO2改善优于对照组(P<0.01),住院天数、插管率及死亡率明显低于对照组(P<0.01)。结论:高海拔地区重症支气管哮喘在常规治疗基础上加NPPV治疗可有效改善症状,纠正缺氧,减少气管插管率,降低病死率,缩短住院时间及降低住院费用。更多还原

【Abstract】 Objective:To evaluate the effect and safety of noninvasive positive pressure ventilation(NPPV) on severe bronchial asthma patients with respiratory failure in high altitude region.Methods: Sixty-eight patients were randomly divided into two groups: the NPPV group received NPPV on the base of routine treatment(NPPV group,n=37);the non-NPPV group only received the routine treatment(non-NPPV group,n=31).Results: Symptom of all patients was alleviated after 2 days treatment.But improvements of pH,PaO2,PaCO2 and SaO2 in NPPV group were more rapid and significant than non-NPPV group at 24 h、72 h(P<0.01).The length of hospital stay,the rate of intubation and mortality of NPPV group were significantly lower than non-NPPV group(P<0.01).Conclusion: Using NPPV based on routine treatment can improve the clinical manifestation and ventilation,and raise the curative effects of severe asthma in high altitude region.更多还原