【摘要】 腺苷是一种遍布人体细胞的内源性核苷,通过其不同类型的受体(A1,A2A,A2B和A3受体)对机体的许多系统(特别是中枢神经系统)及组织发挥着重要的作用,参与调控睡眠、学习记忆、抑郁和焦虑等多种生理和病理过程。随着腺苷对受体亚型选择性激动剂和拮抗剂的开发,人们对腺苷及其受体在外周神经系统中的作用研究越来越深入,并逐步认识到腺苷及其受体与外周痛觉信息的传递和调控密切相关。更多还原

【Abstract】 Adenosine is an endogenous nucleoside that widely exists in the human body cells.Through activating different subgroups of adenosine receptors(A1,A2A,A2B,and A3 receptors),adenosine produces various effects in a broad spectrum of tissues,especially in the central nervous systems,which includes modulating physiological and pathological processes such as sleep,learning and memory,depression as well as anxiety.With the research development in the agonists and antagonists of adenosine receptors,the roles of adenosine and its receptors in the peripheral nervous system have been widely revealed.The researches reported that adenosine and its receptors are closely related to transmission and modulation of nociception in peripheral signals.更多还原