【摘要】 通过富含硫氰酸盐、类黄酮类食物对大鼠食物利用率、肝肾功能的影响观察,结合对甲状腺的损伤,综合探讨此类植物化合物的生物学作用。模拟人体摄入食物类别、剂量及途径,给予实验大鼠不同剂量单一或联合富硫氰酸盐、类黄酮类食物,短期(30d)喂养后,采血及取相关组织分析。表明各实验因素对大鼠进食量影响不明显,联合高剂量组在实验第一周略有下降,但随实验进程延长,后期与其余各组比较差异不明显。对大鼠体重影响不大。单一白菜、豆角组、高剂量组大鼠肝脏系数与对照组比较显著降低(P<0.05、P<0.01、P<0.05);肾脏系数变化不明显;肝脏酶学指标ALT(丙氨酸氨基转移酶)/AST(天门冬氨酸氨基转移酶)各实验组较对照组相比显著减少(P<0.01);血清总胆红素各组与对照组相比均有所减少,白菜组、豆角组、联合中量组(实验组Ⅱ)、联合高剂量组(实验组Ⅲ)更为明显(P<0.01);血清尿素氮(BUN)豆角组、联合低剂量组(实验组I)、联合中剂量组(实验组II)、联合高剂量组(实验组III)与对照组相比显著增加(P<0.05、P<0.01、P<0.05、P<0.05)。结果表明随富硫氰酸盐、类黄酮类食物摄入量的增加,其对机体肝肾功能均有损伤,表现在肝脏更为明显。说明合理适量摄入的重要性,也提示盲目补充硫氰酸盐、类黄酮类会加重肝肾负担,对于有潜在甲状腺病史人群尤应引起重视。更多还原

【Abstract】 The object of this study was to elucidate the effect of Cabbage(thiocyanate) and Beans(flavonoids) extract on the food utilization,liver function and kidney function of rat.For this,The rats divided into different groups according the design of experiment and feeding by different dosage of Cabbage(thiocyanate) and Beans(flavonoids) extract,and then the blood and tissue were extracted after 30 days.It was found that there are without obvious effect on food intake.Compared with the normal control group,single dose of cabbages and beans groups,the joint low-dose group and the joint high-dose group in rats liver coefficient were significantly increased(P<0.05、P<0.01、P<0.05),however,there are no significant effect on kidney coefficient.Compared with the normal control group,each experiment groups ALT/AST are decreased significantly(P<0.01).Compared with the normal control group,it is more significant(P<0.01)in the cabbage group,bean group,middle-dose group(experiment group Ⅱ),high-dose group(experiment group Ⅲ) in rats serum total bilirubin.Compared with the normal control group,single dose of beans groups,the joint low-dose group(experiment group I),the middle-dose group(experiment group II),the joint high-dose group(experiment group III) in rats blood urea nitrogen(BUN) were significantly increased(P<0.05、P<0.01、P<0.05、P<0.05).From the above results,we can draw the conclusion that with thiocyanate,flavonoids increase in food intake,the liver and kidney function were injuries on the body,showing more pronounced in the liver.Also suggested that blindly added thiocyanate,flavonoids will increase the burden of liver and kidney,the potential for thyroid history(hereditary familial,iodine deficiency areas,etc.) people in particular,attention should be paid.更多还原