【摘要】 目的:观察阿托伐他汀对老年2型糖尿病血脂异常患者颈动脉斑块的影响。方法:选择80例2型糖尿病血脂异常患者,随机分为阿托伐他汀治疗组(治疗组,40例)和非阿托伐他汀治疗组(对照组,40例),治疗组每晚顿服阿托伐他汀片10mg,对照组每晚服用一片安慰剂,两组的疗程均为24周。测定两组治疗前和治疗12、24周时患者血脂和血清超敏C-反应蛋白(hs-CRP)水平,并通过彩超观察两组治疗前后颈动脉斑块大小及颈动脉内膜-中层厚度(CI-MT)的变化。结果:治疗12周,治疗组患者胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和hs-CRP均较治疗前明显降低(P<0.05),且颈动脉斑块大小和CI MT较治疗前明显减小(P<0.05),治疗24周时效果更显著(P<0.01)。结论:阿托伐他汀对老年2型糖尿病血脂异常患者具有降脂和抗炎作用,并降低CI MT,减少颈动脉斑块,改善动脉粥样硬化进程。更多还原

【Abstract】 Objective: To observe the effects of atorvastation on carotid atheroma in eldly patients with type 2 diabetes with dyslipidemia.Method: 80 eldly patients with type 2 diabetes with dyslipidemia were selected and randmly divided into two groups.The treatment guoup(n=40) was given oraly 10 microgram of atorvastain every night and the control group was given oraly a placebo every night.Each group received corresponding therapy for 24 weeks.Changes of the serum levels of lipidaemia,hs-CRP and carotid arterial intima-meda thickness(CIMT) before and after treatment were investigated after twelve and twenty-four weeks.Results: After twelve and twenty-four weeks of treatment,the levels of TC,TG,LDL-C,hs-CRP,CIMT and the area of in atorvastain group were decreased than the control group(P<0.05),twenty-four weeks of treatment had apparent results(P<0.01).Conclusion: Treatment by atorvastatin can obviously decrease TC,TG,LDL-C,hs-CRP,CIMT,and improve inflammatory reaction,reduce thearea and ameliorate the carotid atheroma.更多还原