【摘要】 目的研究农村地区居民高血压患病的危险因素。方法采用以人群为基础的病例-对照研究方法。首先运用整群随机抽样法在浏阳市选取3个乡镇的全部居民进行入户调查。然后随机选取普查发现的高血压患者作为病例组,同时选取与病例组在性别和年龄构成上相似,但未患高血压的健康人群为对照组进行研究。应用Logistic回归研究危险因素的独立效应,应用相加模型研究危险因素间的交互作用。结果本研究实际有效调查病例组218例,对照组182例。发现湖南浏阳市农村地区高血压的主要危险因素有超重(OR=4.048)及肥胖(OR=6.476)、向心性肥胖(OR=2.632)、高血压家族史(OR=2.527)。在对混杂因素进行调整后,家族史与超重肥胖及向心性肥胖之间的交互作用的超额相对危险度(RERI)、交互作用归因比(API)及交互作用指数S分别为3.268和0.569、48.365%和14.880%、2.313和1.249。结论湖南浏阳市农村地区居民高血压的发生可能主要与超重及肥胖、向心性肥胖、高血压家族史有关。家族史与超重肥胖及向心性肥胖在高血压的致病中存在较明显的正交互作用。更多还原

【Abstract】 Objective To explore the risk factors of hypertension in a rural area in Hunan Province.Methods A population-based case-control study was used.In the first step,three villages in Liuyang were selected by stratified cluster random sampling method and all local residents were investigated by face-to-face interview.Then some patients with hypertension found in the first step were randomly sampled to case group,while healthy adults with no hypertension and in similar compositions of gender and age with the case group were selected to control group.Independent effects of risk factors were analyzed by Logistic regression,and the interaction among risk factors was analyzed by using an additive effects model.Results Effective investigation data for 218 patients in the case group and 182 healthy people in the control group were used.The main risk factors of hypertension in rural areas of Liuyang,Hunan province were overweight(OR = 4.048),obesity(OR = 6.476),central obesity(OR = 2.632),and family history of hypertension(OR = 2.527).After adjusting some confounding factors,significant positive interaction were observed between family history,overweight/obesity and central obesity;the relative excess risk of interaction(RERI),attributable proportion of interaction(API),and the interaction index(S) were 3.268 vs 0.569,48.365% vs 14.880%,and 2.313 vs 1.249,respectively.Conclusion The cause of hypertension in rural areas of Liuyang,Hunan province was closely related with overweight,obesity,central obesity and family hypertension history.There were positive interactions between family history and overweight/obesity and central obesity in the causes of hypertension.更多还原