【摘要】 目的本文探讨了简单易操作的大鼠慢性温和应激(CUMS)抑郁模型的构建方法。方法将30只Wistar大鼠随机地分为2组,即实验组和对照组。对实验组大鼠实施潮湿笼子、鼠笼倾斜、明暗颠倒、夹尾、禁食、禁水等6种应激因子,历时50d后,用强迫游泳法来检测模型的构建成功与否。结果强迫游泳法中测得的不动时间于实验组与对照组的大鼠有显著性差异,表明CUMS抑郁大鼠模型构建成功。结论应用简单易制作的应激因子也可以构建出CUMS抑郁大鼠模型。更多还原

【Abstract】 Objective This article explores the simple and easy to approach’s method to building the chronic unpredictable mild stress(CUMS) depression model of rats.Methods 30 Wistar rats were randomly divided into two groups,experimental and control groups.Randomly implementing the experimental rats by six stress factors,which are moist cage,declining cage,light and shade reversed,clamping tail,fasting and water deprivation.After 50 days,using the forced swimming experiment to test whether the model building success.Results The forced swimming experiment showed that the immobility time in the experimental group and control group of rats had significant differences,which indicating that the CUMS depression rats model were built successful.Conclusion The stress factor which simple and easy to made can also successful build the CUMS depression rat model.更多还原