【摘要】 采用"交替循环浸泡法（ALIM）"在TiO₂纳米管管内填充类骨磷灰石,使磷灰石涂层由层状结构变为嵌入式结构,并考察填充量与TiO₂纳米管结构间的关系,通过模拟体液浸泡实验评价其生物活性.结果表明,甘油体系（60V电压）中制备的纳米管填充效果最好;无定型的TiO₂纳米管相比锐钛矿相的TiO₂纳米管更能诱导类骨磷灰石的填充;采用ALIM于TiO₂纳米管上填充类骨磷灰石可大大提高其生物活性.更多还原

【Abstract】 A vertically aligned TiO₂ nanotube array was fabricated on the surface of titanium substrate in fluoridecontaining electrolyes by anodization.Alternative Loop Immersion Method（ALIM） was investigated to fill TiO₂ nanotubes with the biological apatite in the saturated solution of Ca（OH）₂ and 0.02 mol/L（NH₄）₂HPO₄.In this way,the structure of the apatite-coating on the Ti substrate was changed for solving the problem of coating shedding well.And the amount of synthetic apatite formed by ALIM was quantified according to key tube properties such as the tube diameter, the layer thickness,the crystal structure（amorphous or anatase）,etc.The effect of filling biological apatite of TiO₂ nanotubes fabricated in glycerol-based electrolyte at 60V is the best.And the rate of inducing biological apatite on amorphous TiO₂ nanotubes with the treatment of ALIM is better than that of anatase TiO₂ nanotubes.Mineralization in vitro experiments indicates that TiO₂ nanotubes after ALIM treatment promote natural apatite formation significantly in a simulated body fluid（SBF）.Such TiO₂ nanotube arrays with ALIM treatment,are useful as a well-adhered bioactive surface layer on Ti implant metals for orthopaedic and dental implants.更多还原