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清脑镇静颗粒的处方优化
Optimization of prescription of Qingnao Zhenjing granules
【摘要】 [目的]采用正交实验优选清脑镇静颗粒的最佳处方。[方法]以颗粒剂吸湿率为指标,采用正交设计实验,对处方配比进行筛选[。结果]优化处方为:干浸膏粉∶糊精∶乳糖∶微晶纤维素=10∶2∶3∶2。优化后清脑镇静颗粒吸湿率较中药浸膏粉有明显降低。[结论]清脑镇静颗粒剂处方合理、工艺可行,符合颗粒剂的质量要求。
【Abstract】 [Objective] To optimize the prescription for Qingnao Zhenjing granules by orthogonal design.[Methods] Moisture rate as an index,in order to optimize the dosage and ultimately determine the prescription,the orthogonal experimental design was used.[Results] The optimizing prescription contains :extracts powder: dioxide ∶ lactose ∶ microcrystalline cellulose=10∶2∶3∶2.[Conclusion] The optimized prescription and technology is reasonable,and conform to the quality requirements of granules.
【关键词】 清脑镇静颗粒剂;
正交实验;
吸湿率;
处方优化;
【Key words】 Qingnao Zhenjing granules; orthogonal design; moisture rate; optimization of prescription;
【Key words】 Qingnao Zhenjing granules; orthogonal design; moisture rate; optimization of prescription;
【基金】 国家科技支撑计划项目(2007BAI41B06)
- 【文献出处】 天津中医药 ,Tianjin Journal of Traditional Chinese Medicine , 编辑部邮箱 ,2011年05期
- 【分类号】TQ461
- 【被引频次】5
- 【下载频次】128