【摘要】 [目的]利用正交实验优选齐墩果酸分散片的最佳处方。[方法]以齐墩果酸溶出度为指标,采用正交设计实验,对处方配比进行筛选。[结果]优化处方为:交联聚维酮(PVPP)∶羧甲基淀粉钠(CMS-NA)∶乳糖∶微晶纤维素(MCC)∶微粉硅胶∶PEG-6000=4∶3∶30∶15∶1∶1。优化后齐墩果酸分散片溶出度为89%,较普通片有明显的提高。[结论]分散片处方合理、工艺可行,符合分散片的质量要求。更多还原

【Abstract】 [Objective] To screen the optimum prescription for oleanolic acid of dispersible tablets by orthogonal design.[Methods] Taking the dissolution rate as an index and using the orthogonal experimental design the prescription match was ultimately determined.[Results] The optimized prescription is: PVPP ∶ CMS-NA ∶ lactose ∶ MCC ∶ silicon gel ∶ PEG-6000=4 ∶ 3 ∶ 30 ∶ 15 ∶ 1 ∶ 1.After optimization the dissolution rate of the dispersible tablets is 89%,showing a significant increasing.[Conclusion] The optimized prescription is reasonable,the technology is feasible.That is tally with the quality requirements of dispersible tablets.更多还原