【摘要】 目的:探讨二胺氧化酶(DAO)活性改变和血清总IgE水平在慢性荨麻疹发病中的意义。方法:采用分光光度法和酶联免疫吸附法测定68例慢性荨麻疹患者和54例健康对照者血清中DAO的活性及血清总IgE水平,并将其活性与病情程度和评分进行相关性分析。结果:慢性荨麻疹组血清DAO的活性在3个不同的时点均低于健康对照组,2组患者血清DAO活性时间效应、组间比较差异均有统计学意义(P<0.01),且分组与时间有交互作用(P<0.01);患者血清DAO活性与其病情的轻、中、重度存在正相关(P<0.05)。慢性荨麻疹患者和健康者在血清总IgE水平上差异有统计学意义(P<0.01),且当血清总IgE≥175IU/mL时,其与病情分级成正相关(P<0.05)。结论:慢性荨麻疹患者血清DAO活性降低及血清总IgE水平过高,可能与其慢性病程及严重程度有关。更多还原

【Abstract】 Objective: To detect the serum activity of diamine oxidase and the total serum IgE levels in chronic urticaria patients, and the significance thereof. Methods: The serum levels of diamine oxidase activity and the total serum IgE were determined by spectrophotometry and enzyme-linked immunosorbent assay in 68 patients with chronic urticaria and 54 healthy controls. The relationship of the activity and the urticaria severity was compared using linear correlation. Results: The serum levels of diamine oxidase activity were lower in three different time points of chronic urticaria group than those of healthy control group. There were significant differences in the serum activity of diamine oxidase and the total serum IgE level between the two groups (P < 0.01). There was a significant difference in the correlation between the activity and the urticaria severity (P < 0.05). There was a significant correlation between the serum diamine oxidase activity and the disease severity (mild, moderate and severe, P < 0.05). There was a significant difference in the total serum IgE level between the two groups (P < 0.01). The serum total IgE was positive correlated with the disease classification, when it was ≥ 175 IU/mL(P < 0.05). Conclusion: The higher level of total serum IgE and the lower serum diamine oxidase activity might be implicated with the chronic pathogenesis and the urticaria severity in chronic urticaria patients.更多还原