【摘要】 目的:探讨天津地区汉族人群白细胞介素(IL)-6-572C/G、IL-1β-511C/T及IL-10-592C/A的基因多态性及其对经皮冠状动脉介入治疗(PCI)术后再狭窄的影响。方法:437例接受PCI并进行冠脉造影随访的患者,按冠脉造影结果分为再狭窄组(166例)和非再狭窄组(271例),用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测IL-6启动子(-572)、IL-1β启动子(-511)及IL-10启动子(-592)位点基因型和等位基因频率的分布。结果:(1)2组IL-6-572C/G、IL-1β-511C/T及IL-10-592C/A基因型和等位基因频率间差异无统计学意义(均P>0.05)。(2)多因素Logistic回归分析显示脂蛋白a、急性冠状动脉综合征(ACS)、术前狭窄程度、靶病变长度为支架内再狭窄(ISR)的可能危险因素(均P<0.05),参照血管直径、支架直径为ISR的可能保护因素(均P<0.05)。结论:IL-6-572C/G、IL-1β-511C/T及IL-10-592C/A基因多态性与天津地区汉族人群再狭窄的发病无关。更多还原

【Abstract】 Objective:To investigate the relationship of inflammatory cytokines gene polymorphism with restenosis after percutaneous coronary intervention (PCI) in Tianjin Chinese-Han population. Methods:Four hundred and thirty-seven patients who successfully underwent PCI with a follow-up angiography were divided into the restenosis group (n = 166) and non-restenosis group (n = 271). The frequencies of IL-6 polymorphism (-572C/G), IL-1β polymorphism (-511C/T) and IL-10 polymorphism (-592C/A) in promoter region were genotyped respectively by restricted fragment length polymorphism using polymerase chain reaction (PCR-RFLP) method. Results:(1) There were no significant differences in frequencies of IL-6-572, IL-1β-511 and IL-10-592 genotype and allele between 2 groups (P > 0.05). (2) Logistic regression analysis revealed a positive correlation between lipoprotein (Lp)a, acute coronary syndrome (ACS), preoperative stenosis, length of target lesion stenosis and restenosis (P < 0.05, respectively); and there was a negative correlations between the stent diameter, the diameter of reference vessel before stent implantation and restenosis(P < 0.05, respectively). Conclusion:There was no association between polymorphism of IL-6 -572 C/G, IL-1β-511 C/T and IL-10 -592 C/A gene and restenosis after PCI in the Tianjin Chinese-Han population.更多还原