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原位凝胶应用于眼部给药系统的研究进展
Progress and advance of in-situ-gel on ophthalmic delivery system
【摘要】 介绍原位凝胶在眼部给药系统中的研究新方法和新进展,以及原位凝胶的不同胶凝机理,分析胶化过程和眼部应用时的影响因素。原位凝胶滴眼剂可以显著延长药物释放,提高药物生物利用度。原位凝胶滴眼剂作为一种新型眼部药物新剂型,具有良好的应用前景。
【Abstract】 To introduce the latest development and method on in stiu gel of ophthalmic delivery system.And mechanisms for in situ gel were introduced.The gelling process and factors in ophthalmologic application were analyzed.The in situ gel could obviously lengthen drug releasing and improved drug bioavailability.In situ gel is as a novel dosage form of ophthalmic delivery with extensive prospect.
【关键词】 原位凝胶;
眼部给药系统;
温度敏感;
pH敏感;
离子强度敏感;
【Key words】 in situ gel; ophthalmic delivery system; temperature sensitive; pH sensitive; ionic strength sensitive;
【Key words】 in situ gel; ophthalmic delivery system; temperature sensitive; pH sensitive; ionic strength sensitive;
- 【文献出处】 天津药学 ,Tianjin Pharmacy , 编辑部邮箱 ,2011年05期
- 【分类号】R943
- 【被引频次】9
- 【下载频次】540