【摘要】 利用纳米磁性颗粒将bFGF定位于大鼠骨骼肌钝挫伤部位,考察该方法对大鼠急性骨骼肌钝挫伤恢复过程中收缩应力及MHC-Ⅱb表达影响。研究结果表明,bFGF对大鼠腓肠肌钝挫伤后第17、24天的收缩力有明显提高。损伤后第2～10天,bFGF包裹组与其余各组之间的MHC-ⅡbmRNA表达差异显著(P<0.05)。因此,磁纳米化的bFGF能明显改善大鼠急性骨骼肌钝挫伤后的收缩应力衰减,显著促进损伤肌肉MHC-ⅡbmRNA的表达,改善损伤肌肉再生和结构修复。更多还原

【Abstract】 To study the effects of basic fibroblast growth factor(bFGF)-coated magnetic nanoparticles on the recovery and regeneration in rat skeletal muscles after acute contusion.bFGF could significantly increased the muscle contractive strength at day 17 and day 24 in gastrocnemius after contusion.From day 2 after contusion,bFGF could restore the muscle relaxation back close to the normal level.The bFGF-coated group was significantly different from other four groups in the expression of at day 2-10 after contusion(P<0.05).The bFGF-coated group could significantly enhance the contractive strength,promote the expression of MHC-Ⅱb mRNA,and improve the regeneration and structure healing of injured muscles in rat acute skeletal muscle contusion.更多还原