【摘要】 目的探讨人生长激素(GH)在多囊卵巢综合征(PCOS)患者实施体外受精(IVF)超排卵中的作用。方法 2008年12月至2010年11月因PCOS排卵障碍而行体外受精-胚胎移植(IVF-ET)的患者121例,以是否使用GH分为两组:GH组48例,对照组73例。比较两组的促性腺激素(Gn)用量、获卵数、优胚率、种植率、冻胚率、妊娠率。结果 GH组和对照组的结果分别如下:Gn用量:(29.18±8.33)和(23.43±8.68)支;获卵数:(10.73±6.0)和(14.0±8.57)枚;优胚率:59.1%和33.33%;种植率:35.30%(36/102)和20.39%(31/152),冻胚率:87.5%(42/48)和58.9%(43/73);妊娠率:56.5%(26/46)和35.3%(24/68)。Gn用量GH组略高于对照组,获卵数GH组略低于对照组。其余各项GH组均明显高于对照组,有统计学意义(P<0.05)。结论 PCOS患者在超排卵早期应用GH可明显提高优胚率、种植率、冻胚率和妊娠率。值得进一步研究及应用。更多还原

【Abstract】 Objective:To observe the effect of applying human growth hormone(GH) during in vitro fertilization to patients with polycystic ovary syndrome(PCOS). Methods:One hundred and twenty-one cycles of in vitro fertilization and embryo transfer in PCOS patients with anovulation from Dec.2008 to Nov.2010 were studied retrospectively.Of these 121 cycles, 48 were with treatment of growth hormone(GH group),73 without GH treatment(control group).The dose of gonadotropin(Gn),the number of retrieved oocytes,good-quality embryo rate,implantation rate, frozen embryo rate,and pregnancy rate were compared. Results:The dosage of Gn was slightly higher in GH group than that in control group(29.18±8.33 vs.23.43±8.68 ampoullas,4U/ampoulla),and the number of retrieved oocytes in GH group was slightly less than that in control group(10.73±6.0 vs.14.0±8.57),but there was no significant difference (P>0.05).The good-quality embryo rate(59.1%vs.33.3%),frozen embryo rate(87.5%vs. 58.9%),pregnancy rate(56.5%vs.35.3%) and implantation rate(35.3%vs.20.4%) in GH group were all significantly higher than those in control group(P<0.05). Conclusions:Early usage of GH in the ovarian hyperstimulation in PCOS patients could significantly improve good-quality embryo rate,implantation rate and pregnancy rate.更多还原