【摘要】 目的通过观察初治鼻咽癌患者放疗的毒副反应,比较分析调强放疗与常规放疗放射反应的差异。方法观察2009年2月-2011年3月80例初治鼻咽癌患者放疗后出现的毒副反应,主要观察急性皮肤反应、急性口咽黏膜反应、血液毒性、张口受限及口干症状。结果调强组患者的急性皮肤反应、口干、张口受限的症状明显低于常规组,差异有统计学意义;口腔黏膜急性反应、血液毒性与常规组无明显差异。结论调强放疗与常规放疗比较,可明显降低急性放射性皮炎、口干及张口受限的发生,而口腔黏膜炎及血液毒性则无明显改善。更多还原

【Abstract】 Objective To compare the acute toxicity of radiotherapy between conventional and intensity-modulated radiation therapy(IMRT) technique for newly diagnosed nasopharygeal carcinoma. Methods Eighty patients with newly diagnosed nasopharygeal carcinoma were treated with conventional radiotherapy or IMRT from Feb 2009 to Jan 2011.Acute toxicities including acute skin reaction,acute radiation-induced mucositis,hematological toxicity,trismus and xerostomia were compared between the two groups. Results The incidence of the acute skin reaction,xerostomia and trismus in conventional radiotherapy group was significantly higher than in the IMRT group.The incidence of mucositis and hematological toxicity was similar in the two groups. Conclusion IMRT can significantly reduce the incidence of acute radiation dermatitis,trismus and xerostomia,while the incidence of mucositis and hematological toxicity is similar in the two groups.更多还原